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在发现毛果芸香碱抗血小板聚集作用的基础上,在家兔血小板实验中进一步证明(1)毛果芸香碱有抑制腺苷二磷酸、花生四烯酸和胶原诱发血小板聚集和释放ATP的作用;对腺苷二磷酸和花生四烯酸诱发的血小板变形无抑制作用,对胶原诱发的变形则有抑制作用。(2)毛果芸香碱对腺苷二磷酸和花生四烯酸诱发的血小板聚集团有解聚作用,但对胶原诱发的则无解聚作用。Nachman等证明的血小板间桥模式不能解释此现象。我们提出了两种有糖蛋白G参与的血小板间桥模式的设想。
On the basis of the anti-platelet aggregation effect of pilocarpine, we further proved in rabbit platelet experiments that (1) pilocarpine can inhibit the platelet aggregation and release of ATP induced by adenosine diphosphate, arachidonic acid and collagen, and that adenosine diphosphate And arachidonic acid-induced platelet degeneration without inhibition, the deformation induced by collagen is inhibited. (2) Pilocarpine depolymerized adenosine diphosphate and arachidonic acid induced platelet aggregation, but did not depolymerize collagen induced. Nachman and other evidence of platelet bridge mode can not explain this phenomenon. We propose two hypothetical modes of platelet bridging with glycoprotein G.