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目的：观察降钙素基因相关肽（ＣＧＲＰ）在过敏性支气管哮喘发病机制中的作用。方法：用猪蛔虫蛋白激发实验犬过敏性支气管哮喘，ＲＩＡ法检测血浆及支气管肺泡灌洗液（ＢＡＬＦ）中ＣＧＲＰ。结果：血浆中ＣＧＲＰ在激发哮喘后１ｈ显著下降，ＢＡＬＦ中ＣＧＲＰ在激发后１ｈ和２ｈ显著低于激发前和激发后即刻的水平。这种变化趋势可能与肺组织中ＣＧＲＰ受体与ＣＧＲＰ结合率的升高有关。结论：研究提示神经原性炎症反应参与支气管哮喘发病机制
Objective: To observe the role of calcitonin gene related peptide (CGRP) in the pathogenesis of allergic bronchial asthma. Methods: Allergic bronchial asthma was induced by Ascaris suum protein in dogs and CGRP in plasma and bronchoalveolar lavage fluid (BALF) by RIA. Results: Plasma CGRP decreased significantly 1 h after asthma, and CGRP in BALF was significantly lower at 1 h and 2 h after challenge than before and immediately after challenge. This trend may be related to the increase of CGRP receptor and CGRP binding rate in lung tissue. Conclusions: The study suggests that neurogenic inflammation is involved in the pathogenesis of bronchial asthma