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目的:研究聚(油酸/亚油酸-癸二酸)-庆大霉素[Poly(OAD/LOAD:SA)庆大霉素]对常见菌是否具有强大的抑菌能力。方法:分别在0.1 mol/L磷酸盐缓冲液(pH 7.4)、蒸馏水、0.9％生理盐水三种介质中测定Poly(OAD/LOAD:SA)-庆大霉素体外释药情况和释出液的抑菌能力。结果:Poly(OAD/LOAD-SA)-庆大霉素在三种介质中的最大释药能力发生在第2日,然后缓慢下降,至第50日尚有相当高浓度的庆大霉素释出,从第2日到第50日,释出液中庆大霉素的浓度分别是对金黄色葡萄球菌和大肠杆菌最小抑菌浓度的59-42128倍和1.8—1314倍;三种介质的释出液对金黄色葡萄球菌和大肠杆菌均有强大的抑菌能力。除从第2日到第14日在磷酸盐缓冲液中的释药和抑菌能力较弱外,药丸在三种介质中的释药特点基本相似。结论:Poly(OAD/LOAD-SA)-庆大霉素用于治疗慢性骨髓炎具有良好的前景。
Objective: To study whether poly (oleic acid / linoleic acid - sebacic acid) - gentamycin [Poly (OAD / LOAD: SA) gentamicin] has strong antibacterial activity against common bacteria. Methods: Poly (OAD / LOAD: SA) - gentamicin in vitro and in vitro were determined in 0.1 mol / L phosphate buffer (pH 7.4), distilled water and 0.9% Antibacterial ability. RESULTS: Poly (OAD / LOAD-SA) - the maximum release capacity of gentamycin in the three media occurred on the 2nd day and then decreased slowly. At the 50th day, there was a relatively high concentration of gentamycin Out, from the 2nd to the 50th, the concentration of gentamicin in the released liquid was 59-42128 times and 1.8-1314 times that of the minimum inhibitory concentration of Staphylococcus aureus and Escherichia coli, respectively; The release solution has a strong antibacterial ability against Staphylococcus aureus and Escherichia coli. In addition to the release from the second day to the fourteenth day in phosphate buffer and antibacterial capacity is weak, the pill in the three media release characteristics are similar. Conclusion: Poly (OAD / LOAD-SA) - gentamicin has a good prospect for the treatment of chronic osteomyelitis.