The purpose of this study was to evaluate the effects of Broussonetia papyrifera (paper mulberry) inva-sion and land use on the floristic composition of a dry semi-deciduous forest in Ghana. Forty-five plots (25 m × 25 m each), distributed among three land uses—selectively log-ged (SL); abandoned farmlands (AF); and an undisturbed reference (RF)—were surveyed. Results showed lower tree species richness (S), diversity (H′), evenness (S) and basal area (BA) in the SL (46, 0.78, 0.32 and 269.12 m2 ha-1, respectively) and AF (40, 0.53, 0.45, and 131.16 m2 ha-1) sites compared to the RF site (79, 2.66, 0.87, 963.72 m2 ha-1). Similar patts were found at the shrub layer, but no differences were observed at the herb layer. Non-metric multidimensional scaling ordination revealed distinct species composition among the land uses. The two disturbed habitats, SL and AF, were associated with increased B. papyrifera invasion particularly in the over-story, with importance value index and mean relative density of 45 and 65.03％, and 42 and 53.29％, corre-spondingly. However, the species was only sparsely rep-resented in the RF site. Tree density of B. papyrifera correlated negatively with H′, S, E, BA, and native tree density and richness. These findings highlight the strong link between human land use (i.e., logging and slash-and-b farming), invasion, and vegetation characteristics, and suggest the need to limit these disturbances to conserve biodiversity within tropical forest ecosystems.