论文部分内容阅读
目的 :调查SARS患者和普通肺炎患者体液免疫的差别。方法 :采用速率散射免疫比浊法检测 5 2例SARS患者 (抗SARS病毒抗体阳性 3 4例 ,阴性 18例 )和 2 6例普通肺炎患者血清免疫球蛋白IgG、IgM、IgA ,补体C3、C4和C反应蛋白 (CRP)的含量。结果 :SARS患者的血清免疫球蛋白IgG、IgM、IgA、补体C3、C4和CRP的含量都高于普通肺炎患者 ,P >0 0 5。抗SARS病毒抗体阳性组的血清免疫球蛋白IgG、IgM含量显著高于普通肺炎患者(P <0 0 1) ;IgA、补体C4和CRP含量也显著高于普通肺炎患者 (P <0 0 5 ) ;C3含量略高于普通肺炎患者 (P >0 0 5 )。抗SARS病毒抗体阴性组血清免疫球蛋白IgG、IgM、IgA、补体C3、C4和CRP含量与普通肺炎患者组差异无显著性。结论 :抗SARS病毒抗体阳性患者组与普通肺炎患者组非特异性体液免疫反应存在显著差别
Objective: To investigate the difference of humoral immunity between SARS patients and ordinary pneumonia patients. Methods: Serum immunoglobulin IgG, IgM, IgA, complement C3 and C4 were detected in 52 SARS patients (34 positive and 18 negative), and 26 normal pneumonia patients by rate nephelometry And C-reactive protein (CRP) levels. Results: Serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP in patients with SARS were higher than those in patients with pneumonia (P> 0.05). Serum immunoglobulin IgG and IgM levels in the anti-SARS antibody positive group were significantly higher than those in the common pneumonia group (P <0.01); IgA, complement C4 and CRP were also significantly higher than those in the common pneumonia group (P <0.05) ; C3 content slightly higher than the common pneumonia patients (P> 0.05). Serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in anti-SARS virus negative group were not significantly different from those in common pneumonia group. Conclusion: There is a significant difference in non-specific humoral immune response between anti-SARS antibody positive patients and normal pneumonia patients