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目的:探讨红细胞CR1基因多态性与结肠癌患者红细胞免疫功能关系。方法:采用回顾性分析的方法,分析我院收治的200例结肠癌患者红细胞免疫功能的临床资料。结果:结肠癌患者RBC-C3bRR、RBC-CR1分子数量明显低于健康对照组,而RBC-CICRR明显高于健康对照组,P<0.05,差异均有统计学意义;结肠癌患者红细胞CR1基因的HH型比例明显高于健康对照组,而HL型、LL型高于对照组,P<0.05,差别均有统计学意义;结肠癌组与对照组相同的基因型患者的RBC-C3bRR经比较无显著性差异,而结肠癌组每种基因型的RBC-CICRR均明显高于对照组,P<0.05。结论:红细胞CR1基因多态性可能是结肠癌患者红细胞免疫功能低下原因之一,但可能还与其他因素有关。
Objective: To investigate the relationship between erythrocyte CR1 gene polymorphism and erythrocyte immune function in patients with colon cancer. Methods: The retrospective analysis of 200 cases of colon cancer patients treated with erythrocyte immune function clinical data. Results: The number of RBC-C3bRR and RBC-CR1 in colon cancer patients was significantly lower than that in healthy controls, while RBC-CICRR was significantly higher than that in healthy controls (P <0.05), and the difference was statistically significant. HH type was significantly higher than the healthy control group, while the HL type, LL type higher than the control group, P <0.05, the difference was statistically significant; colon cancer group and the control group of patients with the same genotype RBC-C3bRR by comparison The RBC-CICRR of each genotype in colon cancer group was significantly higher than that in control group, P <0.05. Conclusion: The polymorphism of erythrocyte CR1 gene may be one of the causes of erythrocyte immune dysfunction in colon cancer patients, but may be related to other factors.