白血病抑制因子（LIF）是一种多功能细胞因子。本文选取55例原发骨肿瘤患者，其中良性患者27例，恶性患者28例，测定其原、血清及其肿瘤组织培养上清液中的LIF浓度，并以3例健康自愿者作对照。结果在对用尿波中无LIF校出。在实验组66份尿液中11份阳性（16．7％），其中27例良性 Leukemia inhibitory factor (LIF) is a multifunctional cytokine. This article selected 55 patients with primary bone tumors, including 27 benign patients and 28 malignant patients. The LIF concentrations in the supernatants of the original, serum, and tumor tissue cultures were determined, and 3 healthy volunteers were used as controls. The results were corrected in the urine wave without LIF. Of the 66 urine samples in the experimental group, 11 were positive (16.7%), of which 27 were benign