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微血管密度异常、血管生长因子(VEGF、PDGF等)及其受体表达异常通过一系列级联反应导致血管异常生长的结果。众多因子均和血管形成有关,在妊娠过程中对胎盘的血管发育有着重要的作用,导致滋养细胞的表型转换障碍、血管结构发育不良、血管生成受阻、血管数目减少,引起胎盘血管重铸障碍,胎儿胎盘单位灌注不足发生流产。研究表明许多自然流产的发生与胎盘组织中血管增生平衡和胎儿血液供应不足有密切关系,从而认为血管生长异常是导致流产的又一重要因素。随着研究的深入进展血管的异常生长与流产的关系是有确定关系的,对于血管生长异常所致的流产,抑制血管各种血管因子的形成、阻止其与受体结合,从而抑制血管的异常生长最终达到克服流产的发展,无异于把幸福带给更多的家庭,不仅是妇产科发展的里程碑,更是人类医学发展史上光辉的一笔。
Abnormal microvessel density, angiogenic growth factors (VEGF, PDGF, etc.) and their receptor expression abnormalities lead to abnormal growth of blood vessels through a series of cascade reactions. Many factors are related to the formation of blood vessels, which play an important role in the development of placental blood vessels during pregnancy, leading to the transformation of trophoblast phenotypes, poorly developed blood vessel structure, blocked blood vessels and reduced blood vessels, causing placental vascular remodeling disorder , Fetal placenta perfusion units lack of perfusion. Studies have shown that many spontaneous abortions are closely related to the balance of vascular proliferation in placental tissue and insufficient blood supply to the fetus. Therefore, it is considered that abnormal blood vessel growth is another important factor in abortion. With the further development of research, the relationship between abnormal blood vessel growth and abortion is determined. Abortion caused by abnormal blood vessel growth, inhibiting the formation of various vascular factors in blood vessels and preventing them from binding with receptors, thus inhibiting the abnormalities of blood vessels Growth eventually overcome the development of abortion, tantamount to bringing happiness to more families, not only a milestone in the development of obstetrics and gynecology, but also a glorious history of the development of human medicine.