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目的 探讨核内不均一核糖核蛋白A2 /B1(hnRNPA2 /B1)在非小细胞肺癌 (NSCLC)中的表达特征及其临床意义。方法 应用免疫组织化学S P法检测hnRNPA2 /B1在 5 8例NSCLC及癌旁组织、支气管切缘和 3 0例肺良性病变肺组织中的表达 ,并分析该蛋白表达与肺癌临床病理特征的关系。结果 NSCLC组织中hnRNPA2 /B1阳性表达率 ( 63 .79% )显著高于癌旁肺组织 ( 4 3 .10 % )和肺良性病变肺组织 ( 2 0 .0 0 % )(P =0 .0 0 0 ) ,癌旁肺组织中hnRNPA2 /B1阳性率亦显著高于肺良性病变肺组织 (P <0 .0 5 )。肺癌患者支气管切缘上皮增生组织阳性表达率 ( 4 0 .0 0 % )显著高于正常支气管上皮 ( 15 .15 % ) (P =0 .0 3 2 )。低分化肺癌hnRNPA2 /B1阳性表达率 ( 78.13 % )显著高于中 -高分化肺癌 ( 4 6.15 % ) (P <0 .0 5 ) ,伴有淋巴结转移肺癌阳性表达率 ( 75 .0 0 % )显著高于无淋巴结转移肺癌 ( 5 0 .0 0 % ) (P <0 .0 5 ) ,Ⅲ +Ⅳ期肺癌阳性表达率 ( 78.5 7% )显著高于Ⅰ +Ⅱ期 ( 5 0 .0 0 % ) (P <0 .0 5 ) ,T3 +T4肺癌阳性表达率 ( 77.42 % )显著高于T1+T2 ( 4 8.15 % ) (P<0 .0 5 )。不同组织学类型肺癌组织中hnRNPA2 /B1表达水平无显著性差异 (P >0 .0 5 )。结论 hnRNPA2 /B1的异常表达在肺癌的发生、发展和转移中?
Objective To investigate the expression and clinical significance of nuclear heterogeneous nuclear ribonucleoprotein A2 / B1 (hnRNPA2 / B1) in non-small cell lung cancer (NSCLC). Methods Immunohistochemical SP method was used to detect the expression of hnRNPA2 / B1 in 58 cases of NSCLC and its adjacent tissues, bronchial margins and lung tissues of 30 benign lung lesions. The relationship between the expression of hnRNPA2 / B1 and the clinicopathological characteristics of lung cancer was analyzed. Results The positive rate of hnRNPA2 / B1 expression in NSCLC was significantly higher than that in adjacent lung (43.10%) and benign lung (20.0%) (P = 0. 0) The positive rate of hnRNPA2 / B1 in paracancer lung tissues was also significantly higher than that in benign lung lesions (P <0.05). The positive rate of bronchoscopic epithelial hyperplasia tissue in lung cancer patients was significantly higher than that in normal bronchial epithelium (40.15%) (40.0%) (P = 0.302). The positive rate of hnRNPA2 / B1 expression in poorly differentiated lung cancer (78.13%) was significantly higher than that in moderate-high differentiated lung cancer (4.13%) (P <0.05), and the positive rate of lung cancer with lymph node metastasis was 75.0% (P <0.05). The positive rate of lung cancer in stage Ⅲ + Ⅳ (78.5 7%) was significantly higher than that in stage Ⅰ + Ⅱ (100.0%) (P0.05) %) (P <0.05). The positive rate of T3 + T4 lung cancer (77.42%) was significantly higher than that of T1 + T2 (4 8.15%) (P <0.05). There was no significant difference in hnRNPA2 / B1 expression in different histological types of lung cancer (P> 0.05). Conclusions Abnormal expression of hnRNPA2 / B1 in lung carcinogenesis, development and metastasis?