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糖尿病患者患冠状动脉粥样硬化性心脏病的发病率是非糖尿病的4倍,近几年来提出的相关发病机制包括Am adori型糖基化合物作用、羧甲基赖氨酸形成、清道夫受体上调、泛素-蛋白酶体系统激活、内质网应激、精氨酸代谢异常、激活血小板源性生长因子途径、透明质烷代谢紊乱和瘦素水平改变等。这些机制的阐述,有利于指导临床对糖尿病性冠状动脉粥样硬化性心脏病及其并发症的预防和治疗。
The incidence of coronary atherosclerotic heart disease in diabetic patients is four times that of non-diabetic patients. The related pathogenesis proposed in recent years includes the action of Am adori-type glycosyl compounds, formation of carboxymethyllysine, and up-regulation of scavenger receptors , Ubiquitin - proteasome system activation, endoplasmic reticulum stress, arginine metabolism, activation of platelet-derived growth factor pathway, hyaluronan metabolic disorders and changes in leptin levels. The elaboration of these mechanisms will help guide the clinical prevention and treatment of diabetic coronary atherosclerotic heart disease and its complications.