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骨组织仅次于肺、肝，是癌症远处转移的第三好发器官 [1]。据统计骨转移瘤的发生率是骨原发恶性肿瘤的 35～ 40倍 [2]。癌症骨转移是癌性疼痛的主要原因之一，它所造成的病理性骨折、脊髓压迫、高钙血症和骨髓衰竭等并发症，加速了病情的发展，严重地影响癌症患者的生存质量。
Bone tissue is second only to the lungs and liver and is the third most common organ for distant metastasis of cancer [1]. According to statistics, the incidence of bone metastases is 35 to 40 times that of primary malignant bone [2]. Cancer bone metastasis is one of the main causes of cancer pain. The complications such as pathological fracture, spinal cord compression, hypercalcemia and bone marrow failure accelerate the development of the disease and seriously affect the quality of life of cancer patients.