论文部分内容阅读
目的了解OPG基因rs2073618、rs3102735位点和RANKL基因rs2277438位点的的单核苷酸多态性与强直性脊柱炎患者遗传易感性的关系。方法采用病例对照研究设计方案,通过高通量SNP检测方法 (多重SNaPshot SNP分型技术),检测213例强直性脊柱炎患者和210例正常对照基因型,并分析基因型及等位基因频率在两组中的分布。结果 OPG基因rs2073618、rs3102735位点和RANKL基因rs2277438位点的等位基因频率和基因型频率在病例组和对照组中的分布差异均无统计学意义(P>0.05)。结论 OPG基因rs2073618、rs3102735位点和RANKL基因rs2277438位点的单核苷酸多态性可能与强直性脊柱炎患者遗传易感性无关。
Objective To investigate the relationship between single nucleotide polymorphism (SNP) of rs2073618, rs3102735 and rs2277438 of RANKL gene in patients with ankylosing spondylitis. Methods The case-control study design was used. 213 cases of ankylosing spondylitis and 210 normal control genotypes were detected by high-throughput SNP detection (multiple SNaPshot SNP typing), and genotype and allele frequency Distribution in both groups. Results There was no significant difference in allele frequency and genotype frequency between rs2073618, rs3102735 and rs2277438 of OPG gene in cases and controls (P> 0.05). Conclusion The single nucleotide polymorphisms of rs2073618, rs3102735 and rs2277438 of OPG gene may not be related to genetic predisposition in patients with ankylosing spondylitis.