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磷酸酰胺天然产物是指生物体产生的含有氮磷键的小分子化合物.因其结构和细胞内磷酸化的生物小分子或羧酸小分子相似,它们竞争生物生命活动某些必需酶的功能,从而表现出各种各样的生物活性.目前已知的磷酸酰胺天然产物氮磷键生物合成机制可以分为3类:Mcc B蛋白催化类、APS腺苷酰基转移酶(adenylyl sulphate:ammonia adenylyltransferase,APSAT)催化类和丙酮酸磷酸二激酶(pyruvate phosphate dikinase,PPDK)同源蛋白催化类.本文就这3类氮磷键生物合成机制进行综述.
Phosphoric acid amide natural product is a small molecule compound containing nitrogen and phosphorus bond produced by organism, which competes for the function of some essential enzymes of biological life activity because of its structure similar to the intracellular phosphorylated biological small molecule or carboxylic acid small molecule, Thus showing a variety of biological activity.At present, the natural products of phosphoric acid amide nitrogen and phosphorus bond biosynthesis mechanism can be divided into three categories: Mcc B protein catalysis, APS adenyllyl transferase (adenylyl sulphate: ammonia adenylyltransferase, APSAT) and pyruvate phosphate dikinase (PPDK) homologous protein catalysis.In this paper, the mechanism of these three types of nitrogen and phosphorus bond biosynthesis is reviewed.