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反复自然流产与子宫畸形和染色体异常有关,但多数病例原因不明。许多学者认为涉及某种难确定的免疫学过程,并得到下述证据支持:(1)流产夫妇共有较多A和B位点的HLA抗原,作者也证实了这一点并引伸到包括C和DR位点;(2)习惯性流产者不产生正常妊娠母血中见到的细胞免疫抑制因子;(3)研究发现人滋养层膜中缺乏移植抗原而存在分离的抗原,这可能成为母胎间免疫反应的基础;(4)有些滋养层抗原是同种异型的,并与白细胞共有。这提示夫妇间共有HLA抗原
Repeated spontaneous abortion and uterine malformations and chromosomal abnormalities, but the reasons for most cases unknown. Many scholars believe that some difficult immunological processes are involved and supported by the following evidences: (1) There are more HLA antigens in abortion couples with more A and B sites, and the authors confirm this and extend to include C and DR Site; (2) habitual abortion does not produce cellular immunosuppressive factors seen in normal gestational maternal blood; (3) studies have found that the absence of the transplanted antigen in the human trophoblast membrane exists for the presence of isolated antigens, which may become immunocompetent (4) Some trophoblast antigens are allotyped and shared with leukocytes. This suggests that the couple shared HLA antigens