[Object] To optimize the extraction process of total phenolic compounds from Paeonia suffruticosa Andr..[Method] Extraction time of 30 min,ethanol concentration,extraction temperature and solid-liquid ratio were chosen as the response factors,the extraction rate of total phenolic compounds as index.The best combination of extraction parameters was obtained by response surface methodology at a three-variable,three-level experiment.[Result]The optimum extraction parameters were as follows:50% ethanol,extraction temperature of 75 ℃,solid-liquid ratio of 1:41.Under the above conditions the maximal yield of phenolic compounds reached 40.95 mg/g,which was consistent with model predictions.[Conclusion] The study would provide scientific proof for the deeper utilization and extensive application of Paeonia suffruticosa Andr. [Object] To optimize the extraction process of total phenolic compounds from Paeonia suffruticosa Andr .. [Method] Extraction time of 30 min, ethanol concentration, extraction temperature and solid-liquid ratio were chosen as the response factors, the extraction rate of total phenolic compounds as index. The best combination of extraction parameters was obtained by response surface methodology at a three-variable, three-level experiment. [Result] The optimum extraction parameters were as follows: 50% liquid ratio of 1: 41.Under the above conditions the maximal yield of phenolic compounds reached 40.95 mg / g, which was consistent with model predictions. [Conclusion] The study would provide scientific proof for the deeper utilization and extensive application of Paeonia suffruticosa Andr .