论文部分内容阅读
目的评价松茸、桑白皮、虎杖及葛根提取物对酪氨酸酶活性及黑色素合成的抑制作用,为美白类产品的开发提供试验依据。方法测定不同浓度松茸、桑白皮、虎杖及葛根提取物对酪氨酸酶活性,B16细胞增殖的影响及对B16细胞内黑色素含量及酪氨酸酶活性的抑制作用。以阳性药光甘草定作为对照。采用SigmaStat软件进行统计学处理。结果在B16细胞模型中,松茸提取物抑制活性优于桑白皮、虎杖和葛根提取物(P<0.05),高浓度(25 mg/L)松茸提取物对黑色素合成及酪氨酸酶活性的抑制率分别为(46.70±7.79)%和(65.73±0.58)%,与光甘草定的作用效果相当[抑制率分别是(30.48±3.05)%和(73.53±0.80)%]。结论高浓度松茸提取物对酪氨酸酶活性及黑色素合成的抑制作用与光甘草定相当,其作为天然来源的皮肤美白剂具有一定的开发潜力。
Objective To evaluate the inhibitory effect of matsutake, Morus alba, Polygonum cuspidatum and Pueraria lobata on tyrosinase activity and melanin synthesis, and provide experimental basis for the development of whitening products. Methods The effects of different concentrations of matsutake, Morus alba, Polygonum cuspidatum and Pueraria lobata on the tyrosinase activity, the proliferation of B16 cells and the inhibition of melanin content and tyrosinase activity in B16 cells were determined. The positive drug licorice as a control. Using SigmaStat software for statistical analysis. Results The inhibitory activity of Matsutake was superior to that of Morus alba, Polygonum cuspidatum and Pueraria lobata (P <0.05) in B16 cell model. The effect of Matsutake extract at high concentration (25 mg / L) on melanin synthesis and tyrosinase activity The inhibitory rates were (46.70 ± 7.79)% and (65.73 ± 0.58)%, respectively, which were comparable to those of Guangcaoding [inhibition rates were (30.48 ± 3.05)% and (73.53 ± 0.80)%], respectively. Conclusion The extract of Tricholoma matsutake has the same inhibitory effect on tyrosinase activity and melanin synthesis as Bromhidium, which has potential for development as a natural skin whitening agent.