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本文建立二肾一夹型肾血管性高血压大鼠(2KIC-RHR)动物模型,观察大鼠在高血压稳定期血小板胞浆内游离钙浓度([Ca~(2+)]_i)及血小板聚集率(PAg)的变化并研究了ACEI—卡托普利对高血压大鼠血小板内[Ca~（2+）]_i及血小板聚集功能的影响.结果发现:高血压大鼠血小板内[Ca~（2+）]_i及血小板聚集率均显著升高(P<0.01),卡托普利显著降低血压同时血小板内[Ca~（2+）]_i、血小板聚集率也明显减小(P<0.01).提示:2KIC—RHR在高血压稳定期存在血小板内钙代谢异常和血小板功能的改变,血小板活性的降低可能参与卡托普利的降压作用.
In this study, we established a rat model of 2KIC-RHR and observed the changes of intracellular free calcium concentration ([Ca2 +] i) and platelets (PAg) and the effect of ACEI-captopril on [Ca ~ (2 +)] i and platelet aggregation in platelet of hypertensive rats.Results: (2 +)] i and platelet aggregation rate were significantly increased (P <0.01), while captopril significantly decreased blood pressure and platelet [Ca ~ (2 +)] i, platelet aggregation was also significantly reduced <0.01) .Conclusion: 2KIC-RHR is associated with abnormal platelet calcium metabolism and platelet function during stable period of hypertension, and the decrease of platelet activity may be involved in the antihypertensive effect of captopril.