头孢拉定是目前监床上常用的一种抗生素,尤其是治疗下呼吸道感染疗效显著,但其肾毒性往往不被重视。现将我科近期住院病人中应用头孢拉定的患儿进行观察的结果报告如下。1 临床资料和方法1.1 病例选择 共81例下呼吸道感染患儿,年龄2～12岁,既往无肾脏病史,近7～10天未用其他药物。1.2 方法 采用GC—1200γ放射免疫计数器,北京市福瑞生物工程公司提供的β_2-微球蛋白(β_2- Cefradine is currently an antibiotic commonly used on supervisory beds, especially for the treatment of lower respiratory tract infection, but its nephrotoxicity is often not taken seriously. The recent hospitalization of patients with cefradine in our hospital for the observation of the results reported below. 1 Clinical data and methods 1.1 Case Selection A total of 81 cases of children with lower respiratory tract infection, aged 2 to 12 years old, no previous history of kidney disease, nearly 7 to 10 days without the use of other drugs. 1.2 Methods GC-1200γ radioimmunoassay, Beijing Fu Rui Bioengineering provided β_2-microglobulin (β_2-