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目的 观察雷贝拉唑三联短程疗法根除幽门螺杆菌及治疗十二指肠溃疡的疗效。方法 12 0例经胃镜检查确诊为十二指肠溃疡并经快速尿素酶实验和病理学检查确定为Hp阳性的病人随机分为两组 :雷贝拉唑组和奥美拉唑组。两组先予以三联疗法 :雷贝拉唑 10mg或奥美拉唑 2 0mg、阿莫西林 1g及克拉霉素 5 0 0mg ,每日 2次 ,连续 7d ,然后予雷贝拉唑 10mg或奥美拉唑 2 0mg ,每天 1次 ,连续 7d ,疗程结束后 4周复查胃镜并检测Hp ,并记录用药后病人症状的改变程度。结果 113例完成治疗方案。其中雷贝拉唑组Hp根除率为 93 0 % ,奥美拉唑组为 85 7% ,两组间差异无显著意义 (P >0 0 5 ) ;雷贝拉唑组 2周溃疡愈合率为 94 7% ,奥美拉唑组为 78 6 % ,雷贝拉唑组明显高于奥美拉唑组 ,两组差异有显著意义 (P <0 0 5 ) ;雷贝拉唑组第 1、3d症状缓解率分别为 70 1%、91 2 % ,奥美拉唑组为 39 3%、6 7 8% ,两组比较差异有显著意义 (P<0 0 5 )。结论 雷贝拉唑、克拉霉素和阿莫西林三联短程疗法能有效根除Hp及高溃疡愈合率 ,并能迅速缓解症状 ,与奥美拉唑三联疗法相比较 ,在Hp根除率上差异无显著意义 ,在 2周溃疡愈合率及症状缓解率方面 ,雷贝拉唑要明显优于奥美拉唑。
Objective To observe the efficacy of rabeprazole triple short-course therapy for the eradication of Helicobacter pylori and the treatment of duodenal ulcer. Methods One hundred and twenty patients diagnosed as duodenal ulcer by gastroscopy were randomly divided into two groups: rabeprazole group and omeprazole group, all of which were identified as Hp positive by rapid urease test and pathological examination. The two groups were given triple therapy: rabeprazole 10mg or omeprazole 20mg, amoxicillin 1g and clarithromycin 500mg, 2 times a day for 7 days, and then to rabeprazole 10mg or Ogilvy & Mather Lazole 20mg once daily for 7 days. The endoscopy was performed 4 weeks after the end of the course of treatment and the Hp was tested. The degree of change of the patient’s symptoms was recorded. Results 113 cases completed the treatment. Among them, the eradication rate of Hp in rabeprazole group was 93.0% and that in omeprazole group was 85.7%, there was no significant difference between the two groups (P> 0.05); the healing rate of 2-week rabeprazole group was 94.7% in the omeprazole group, and 78.6% in the omeprazole group. The rabeprazole group was significantly higher than the omeprazole group (P <0.05) The rates of 3d remission were 70.1% and 91.2% respectively, while those in omeprazole group were 39.3% and 67.8% respectively. There was significant difference between the two groups (P <0.05). Conclusion Rabeprazole, clarithromycin and amoxicillin triple short-term therapy can effectively eradicate Hp and high ulcer healing rate, and can quickly relieve symptoms, and omeprazole triple therapy compared to the Hp eradication rate difference was not significant Significance, rabeprazole was significantly better than omeprazole in 2 weeks ulcer healing rate and symptom response rate.