Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

来源 :高等学校化学研究：英文版 | 被引量 : 0次 | 上传用户：Jason51090

【摘要】

：

The improved 3-step preparation of a key antitumor agent, 7-ethyl-10-hydroxycamptothecin(SN-38), which consists of ethylation, oxidation and photo-chemical rear

【作者】

：

LEI Ying-jie

【出处】

：

高等学校化学研究：英文版

【发表日期】

：

2001年1期

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The improved 3-step preparation of a key antitumor agent, 7-ethyl-10-hydroxycamptothecin(SN-38), which consists of ethylation, oxidation and photo-chemical rearrangement, is described. The proposed reaction mechanism is also discussed.

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Synthesis of 7-Ethyl-10-hydroxycamptothecin and Proposed Reaction Mechanism

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