论文部分内容阅读
目的探讨血管性疾病患者心踝血管指数(CAVI)与高同型半胱氨酸血症(HHcy)之间的相关性。方法选择高血压、冠心病患者63例,根据血浆同型半胱氨酸(Hcy)水平分为对照组(35例)及HHcy组(28例)。应用动脉僵硬度自动检测装置测定CAVI作为反映动脉僵硬度的指标。结果 HHcy组CAVI、颈-股脉搏波传导速度(CFPWV)显著高于对照组(9.59±2.47 vs.7.77±1.86,P=0.002;13.54±3.28 vs.10.63±2.65,P<0.001)。63例患者中血浆Hcy与年龄、CFPWV、CAVI分别呈正相关(r分别为0.357,0.331,0.417;P均<0.05)。校正年龄、性别因素后,Hcy与CFPWV、CAVI仍呈正相关(r=0.260及0.316,P均<0.05)。多元线性回归分析显示Hcy是CAVI的独立影响因素(β=0.447,P=0.013)。结论HHcy患者CAVI水平显著升高,提示Hcy参与了动脉僵硬度的发生进展过程。
Objective To investigate the correlation between heart and ankle vascular index (CAVI) and hyperhomocysteinemia (HHcy) in patients with vascular diseases. Methods 63 patients with hypertension and coronary heart disease were divided into control group (n = 35) and HHcy group (n = 28) according to plasma homocysteine level. CAVI was measured as a measure of arterial stiffness using an automatic arterial stiffness test device. Results The CAVI and CFPWV of the HHcy group were significantly higher than those of the control group (9.59 ± 2.47 vs.7.77 ± 1.86, P = 0.002; 13.54 ± 3.28 vs.10.63 ± 2.65, P <0.001). The plasma Hcy in 63 patients was positively correlated with age, CFPWV and CAVI (r = 0.357,0.331,0.417, P <0.05 respectively). After adjusting for age and gender, Hcy was still positively correlated with CFPWV and CAVI (r = 0.260 and 0.316, P <0.05). Multivariate linear regression analysis showed that Hcy was an independent predictor of CAVI (β = 0.447, P = 0.013). Conclusions The level of CAVI in patients with HHcy is significantly increased, suggesting that Hcy is involved in the progression of arterial stiffness.