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平原地区(10m)狗进入高原(4080m)3年后(A组)与高原土生狗(B组)重返平原(20m)3个月后的肾脏及其AKP活性变化的电镜对比观察。结果:1.A组肾小球部分毛细血管基膜呈分层样变,足细胞部分足突融合;肾小管上皮细胞部分绒毛扩张,细胞间隙增宽等超微结构仍未得到恢复。2.A、B组肾小球毛细血管内皮细胞、足细胞和肾小管上皮细胞内的线粒体、内质网束见变性和数量变化;肾小管上皮细胞内糖原易见。3.A组肾小管上皮细胞微绒毛膜上和细胞褶膜上的AKP呈少量褐色、细颗粒状,稀疏分布或无AKP存在。
Electron microscopic observation of the changes of AKP activity in kidney and its kidneys in the plains (10m) three months after the plateau (4080m) entered the plateau (group A) and the plateau indigenous dog (group B) returned to the plains (20m) Results: 1.A group of glomerular capillary basement membrane was stratified, podocyte foot process fusion; part of renal tubular epithelial cells villus expansion, widening cell gap and other ultrastructures have not been restored. 2.A, B group of glomerular capillary endothelial cells, podocytes and tubular epithelial cells mitochondria, endoplasmic reticulum see degeneration and quantitative changes; tubular epithelial cells glycogen easily seen. 3.A group of renal tubular epithelial cells on the microvilli and pleat membrane on the AKP showed a small amount of brown, fine granular, sparsely distributed or no AKP exists.