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目的探讨急性脑梗死患者血浆脂联素(adiponectin,APN)及高敏C反应蛋白(high-sensitive C-reactive protein,Hs-CRP)水平变化与预后的相关性。方法 147例急性脑梗死患者采用头颅MRI的DWI计算梗死容积,进一步分为大、中、小梗死组,分别在治疗前、治疗第7天、第14天测定APN与Hs-CRP,同时进行临床神经功能损害程度评价,对结果进行分析。结果随着梗死容积增大,APN降低,Hs-CRP升高,经过治疗逐渐恢复。随着梗死容积增大,NIHSS逐步升高,BI逐渐下降,治疗后NIHSS明显下降而BI明显升高。随着梗死容积增大,APN降低而Hs-CRP升高,同时NIHSS升高而BI降低。APN与NIHSS呈负相关,APN与BI呈正相关,Hs-CRP与NIHSS呈正相关,Hs-CRP与BI呈负相关。结论血浆APN、Hs-CRP水平与脑梗死病情的严重程度密切相关,定期检查APN、Hs-CRP对评估脑梗死的预后很有价值。
Objective To investigate the relationship between plasma adiponectin (APN) and high-sensitive C-reactive protein (Hs-CRP) levels and prognosis in patients with acute cerebral infarction. Methods 147 cases of acute cerebral infarction patients with cerebral infarction volume by MRI, further divided into large, medium and small infarction group, respectively, before treatment, the treatment of APN and Hs-CRP on the 7th and 14th day, while clinical Evaluation of the degree of neurological impairment, the results were analyzed. Results With the increase of infarct volume, APN decreased and Hs-CRP increased, and gradually recovered after treatment. With the increase of infarct size, NIHSS gradually increased, BI gradually decreased, NIHSS decreased significantly after treatment and BI was significantly higher. As infarct volume increases, APN decreases and Hs-CRP increases, while NIHSS increases and BI decreases. APN was negatively correlated with NIHSS, APN positively correlated with BI, Hs-CRP positively correlated with NIHSS, and Hs-CRP negatively correlated with BI. Conclusion The plasma levels of APN and Hs-CRP are closely related to the severity of cerebral infarction. Regular examination of APN and Hs-CRP is of great value in assessing the prognosis of cerebral infarction.