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桂姜草枣黄辛附汤提取剂(TJ-8023)临床用于治疗风湿、腰痛、神经痛。口服TJ-8023能显著抑制反复冷应激(RCS)诱导的大鼠痛觉过敏。本实验测定鞘内注射5-羟色胺(5-HT)能受体拮抗药和5-HT对TJ-8023镇痛作用的影响,进一步探讨了TJ-8023的作用机理。
Gui Jiang Cao Zao Huang Xin Tang Decoction (TJ-8023) is used clinically to treat rheumatism, low back pain, and neuralgia. Oral TJ-8023 significantly inhibited hyperalgesia induced by repeated cold stress (RCS) in rats. This experiment measured the effect of intrathecal 5-hydroxytryptamine (5-HT) receptor antagonist and 5-HT on the analgesic effect of TJ-8023, and further explored the mechanism of action of TJ-8023.