目的：为了探讨一步成囊法制备的海藻酸钠微囊对猪胰岛样细胞团（Ｉｓｌｅｔｌｉｋｅｃｅｌｃｌｕｓｔｅｒ，ＩＣＣ）的保护作用。方法：本研究把经猪ＩＣＣ免疫的小鼠新鲜血清，与微囊化ＩＣＣ或游离ＩＣＣ共同孵育后，观察各组ＩＣＣ的胰岛素释放试验。结果：微囊ＩＣＣ组的基础及刺激后的胰岛素值分别为９３４９±１６２１，２７５００±３５１９ｍＵ／Ｌ，与对照组比较差异无显著性（Ｐ＞００５）；游离ＩＣＣ组的基础及刺激后胰岛素值分别为６６８３±１０２４，９２４１±２５３２ｍＵ／Ｌ，明显低于微囊ＩＣＣ组及对照组（Ｐ＜００１）。结论：表明免疫血清对游离ＩＣＣ有明显损害，而海藻酸钠微囊对特异性抗体有免疫隔离作用，能够保护ＩＣＣ免遭抗体攻击 Objective: To investigate the protective effect of sodium alginate microcapsules prepared by one-step capsule method on Isletlikecel cluster (ICC). Methods: In this study, the fresh serum of mice immunized with porcine ICC was incubated with microencapsulated ICC or free ICC to observe the ICC insulin release test. Results: The basis of microcapsule ICC group and the stimulated insulin value were 9349 ± 1621 and 27500 ± 3519 mU / L, respectively. There was no significant difference between the ICC group and the control group (P> 005). The basal and stimulated insulin values ​​in free ICC group were 6683 ± 1024 and 9241 ± 2532mU / L, respectively, which were significantly lower than those in ICC group and control group (P <001). CONCLUSIONS: The immune serum shows significant damage to free ICCs, whereas sodium alginate microcapsules have immunosuppressive effects against specific antibodies and are able to protect ICCs from antibody challenge