论文部分内容阅读
目的 探讨肝豆状核变性的颅脑MRI表现特点与病程及神经体征的关系.资料与方法 对临床和实验室检查证实的93例肝豆状核变性患者均进行颅脑MRI平扫.对颅脑有异常表现的病例根据病程分为三组,采用χ~2检验评估病程与病变部位的相关性.结果 颅脑MRI无异常发现15例,有异常发现78例,有6例仅表现为脑萎缩,阳性率为83.9%.脑MRI异常信号发病部位依次为豆状核(69/72)、中脑(28/72)、尾状核头(17/72)、丘脑(24/72)、桥脑(23/72)、额叶(7/72)、胼胝体压部(4/72)、齿状核(6/72)、小脑中脚(1/72)、枕叶(1/72),脑萎缩59例.桥脑病变与病程有统计学意义(χ~2值=6.488,P值<0.05),其他病变部位与病程无统计学意义.结论 肝豆状核变性颅脑M砌表现与临床症状关系尚难确定,与病程无明显相关性.“,”Objective To explore the MRI features of HLD,and to study the correlations between the MRI features with clinical data,such as the duration of the disease and the neurologic symptoms in HLD.Materials and Methods 93 patients with HLD confirmed by clinical and experiment results performed plain MRI scanning.The cases with abnormal appearances were divided into 3 groups accorded to the duration of the disease.The correlation between the abnormal appearances and the duration of the disease was compared with χ~2 test.Results Among the 93 patients,15 of brain were showed normal and 78 abnormal on MRI.The positive rate of MRI finding was 83.9%.The abnormal MRI signal were located in the double or single basal ganglia,brain stem,thalami,lobus frontalis,splenium corporis-occipitalis,dentate nucleus,pedunculus cerebellaris medius,lobus occipitalis and/or brain atrophy.The lesions involved the nucleus lentiformis in 69(69/72),the mesencephalon in 28(28/72),the caput nuclei caudati in 17(17/72),the thalami in 24(24/72),the pons in 23(23/72),the lobus frontalis in 7(7/72),the splenium corporis-occipitalis in 4(4/72),the dentate nucleus in 6(6/72),the pedunculus cerebellaris medius in 1(1/72),the lobus occipitalisin 1(1/72),brain atrophy in 59(59/93).There was correlation between the abnormal appearances located in the pons and the duration of the disease(χ~2 =6.488,P<0.05).There was no correlation between the abnormal appearances located in other regions and the duration of the disease.Conclusion It is difficult to decide the correlation between the MRI findings and the neurologic symptoms in patients with HLD.There was no significant correlation between the MRI finding and the duration of the disease in HLD cases.