“冠心Ⅰ号”(以下简称“冠Ⅰ”)的系统药理研究已另文报告。在研究其“抗心肌缺血”实验中发现,经腹腔注射“冠Ⅰ”的大白鼠大多出现心率减慢,提示可能有抗快速型心律失常的作用。“冠Ⅰ”在临床试用也发现有抗心律失常的效果。据此我们参照抗心律失常药筛选规程进行了“冠Ⅰ”抗心律失常的进一步实验研究。“冠Ⅰ”(冠脉乐)由福建省三明真菌研究所提供,系来自斑褐孔菌Suscoporia Punctata(Fr.)Cunn的菌丝部分,pH6.4,小白鼠的LD_(50)=54g/kg,LD_(50)的95％可信限为49.3～59.2g/kg。 The systematic pharmacological study of Guanxin I (hereinafter referred to as “crown I”) has been reported separately. In the study of its “anti-myocardial ischemia” experiment, it was found that most of the mice injected intraperitoneally with “crown I” experienced a slowing of the heart rate, suggesting that they may have the effect of resisting rapid arrhythmia. “Crest I” also found anti-arrhythmic effects in clinical trials. Based on this, we conducted a further experimental study of “Crown I” antiarrhythmia with reference to antiarrhythmic drug selection procedures. “Guan I” (Guanmai Le) was provided by the Sanming Institute of Fungi, Fujian Province, and was derived from the mycelium portion of Succoporia Punctata (Fr.) Cunn, pH 6.4, LD_(50) = 54g/rat. The 95% confidence limit for kg, LD_(50) was 49.3 to 59.2 g/kg.