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目的:探讨肿节风挥发油对人胃癌细胞的抑制和诱导细胞发生凋亡的作用。方法:用MTT法、琼脂糖凝胶电泳和流式细胞仪的方法,观察肿节风挥发油对人胃癌细胞(SGC-7901)凋亡及细胞DNA周期的影响。结果:MTT法表明肿节风挥发油对SGC细胞有抑制作用,并呈现剂量依赖性;肿节风挥发油(0.538、0.269mg/m l)作用SGC细胞48h后,琼脂糖凝胶电泳呈典型的“梯状(DNA ladder)”带;流式细胞仪检测结果显示,肿节风挥发油可引起SGC细胞G0/G1期细胞增加,S期细胞减少,呈现G0/G1期阻滞现象,并有诱导细胞凋亡作用。结论:肿节风挥发油对人胃癌细胞(SGC-7901)有抑制和灭杀作用,而这种作用的机制之一是通过诱导人胃癌细胞发生凋亡。
OBJECTIVE: To investigate the effect of volatile oil from Sjogicum on inhibition of human gastric cancer cells and the induction of cell apoptosis. Methods: MTT assay, agarose gel electrophoresis and flow cytometry were used to observe the effect of swollen oil on the apoptosis and DNA cycle of human gastric cancer cell line SGC-7901. Results: MTT assay showed that the swollen oil of Sjogren’s can inhibit SGC cells in a dose-dependent manner. After treated by Sjogren’s Volatile Oil (0.538,0.269mg / ml) for 48 hours, the agarose gel electrophoresis showed a typical " The result of flow cytometry showed that the volatile oil from Sect.of Arthropod could increase the cells in G0 / G1 phase and reduce the cells in S phase, which showed the phenomenon of G0 / G1 phase arrest and induced Apoptosis. Conclusion: Volatile Oil from Zedoariae has inhibitory and extermination effects on human gastric cancer cells (SGC-7901), and one of the mechanisms of this effect is through the induction of apoptosis in human gastric cancer cells.