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ClC(voltage gatedchloridechannel)通道是迄今发现的唯一电压门控氯离子通道 ,在细胞兴奋性调节、细胞容积调节和跨上皮物质转运等生理过程的调节中发挥重要作用。本文讨论了目前已经发现的ClC通道的分类、分布、结构和功能 ,以及与其有关的致病机制
ClC (voltage gated chloride channel) is the only voltage-gated chloride ion channel discovered so far, which plays an important role in the regulation of physiological processes such as excitability regulation, cell volume regulation and trans-epithelial transport. This article discusses the classification, distribution, structure and function of the ClC channels that have been discovered so far, as well as the related pathogenic mechanisms