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目的:对已建立以指纹图谱表达的中药多成分体系的药物动力学,亦谱动学的总量统计矩数学模型进行实验验证。方法:以补阳还五汤中黄芪甲苷、芍药苷与苦杏仁苷3成分为模型药物,采用反相高效液相色谱法测定,分别用成分叠加拟合、总量统计矩、线性谱动学、梯形谱动学四计算法求算出3成分的谱动学总量统计矩参数。结果:其中线性谱动学计算的总量统计矩参数分别为VUCT为(118.8±14.56)mg·min·mL-1;MRT T为(168.6±6.564)min;VRTT为(89 670±2 089)min2;ClT为(0.4556±0.03505)mL·min-1·kg-1;VT为(76.90±5.238)mL/kg;t0.95T为(622.2±16.89)min;λ0.95T为(106.1±0.6339)min。结论:3成分总量的半衰期为(116.8±5.503)min,3药在0-622.2min内代谢95%的浓度。四法参数无显著性差异。所建立的中药谱动学数学模型及参数体能表征中药多成分体系药物动力学行为。
OBJECTIVE: To validate the pharmacokinetic and pharmacokinetic models of total multi-component maths that have been established by fingerprinting. Methods: Astragaloside 3, paeoniflorin and amygdalin in Buyang Huanwu Decoction were used as model drugs and determined by reversed-phase high-performance liquid chromatography. Compositions were fitted by fitting, total statistical moment and linear spectrum Learning, trapezoidal spectroscopy four calculation method to calculate the three components of the total kinetic statistics of the moment parameters. Results: Among them, the parameters of VFT were (118.8 ± 14.56) mg · min · mL-1; MRT T was (168.6 ± 6.564) min; VRTT was (89 670 ± 2 089) min, ClT was (0.4556 ± 0.03505) mL · min-1 · kg-1, VT was (76.90 ± 5.238) mL / kg, t0.95T was (622.2 ± 16.89) min and λ0.95T was (106.1 ± 0.6339) min. CONCLUSION: The half-life of the three components was (116.8 ± 5.503) min. The three drugs metabolized 95% within 0-622.2 min. No significant difference between the four parameters. The established pharmacokinetic mathematical model of traditional Chinese medicine and parameters of the physical fitness of multi-component system pharmacokinetic behavior.