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锌是生命必须元素,在体内是仅次于铁的第二大微量元素。锌对细胞的新陈代谢具有重要作用。锌在中枢神经系统中广泛分布,大约10%的锌以螯合物形式存在(ZN2+)存在于神经元的轴突末梢。研究表明,螯合的ZN2+常存在于谷氨酸能神经元的突触囊泡中。NMDA受体是ZN2+调节兴奋性传递的靶点之一。NMDA受体在
Zinc is an essential element of life, is the second largest trace element in the body after iron. Zinc plays an important role in cell metabolism. Zinc is widely distributed in the central nervous system and about 10% of zinc is present as a chelate (ZN2 +) in the axon terminals of neurons. Studies have shown that chelated ZN2 + is often found in synaptic vesicles of glutamatergic neurons. NMDA receptor is one of the targets of ZN2 + regulating excitatory transmission. NMDA receptor in