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目的 探讨诱导痰在慢性咳嗽患者气道炎症评价中的作用。方法 收集我院就诊的慢性咳嗽患者86例,进行诱导痰细胞学分类,测定上清液嗜酸性粒细胞阳离子蛋白(ECP)和白细胞介素8 (IL 8)。结果 77例明确诊断,其中咳嗽变异型哮喘24例,嗜酸性粒细胞支气管炎13例,鼻后滴漏综合征22例,胃食管反流12例,双病因6例;病因未明9例。咳嗽变异型哮喘及嗜酸性粒细胞支气管炎组诱导痰嗜酸性粒细胞(0. 172±0. 140, 0. 186±0. 163)、中性粒细胞(0. 411±0. 205, 0. 401±0. 191)、ECP[ (3. 12±2. 12)mg/L,(2. 53±2. 07 )mg/L]和IL 8 [ ( 7. 84±1. 93 )μg/L, ( 7. 63±6. 47 ) μg/L]与正常对照组[ 0. 002±0. 002;0. 223±0. 102; (0. 11±0. 07)mg/L; (1. 06±0. 98)μg/L]比较有统计学差异(P<0. 01或P<0. 05);但两组间以上各指标均无统计学差异。鼻后滴漏综合征组和胃食管反流组诱导痰嗜中性粒细胞( 0. 555±0. 288,0. 504±0. 304)与正常对照组比较有统计学差异(P<0. 01)。鼻后滴漏综合征组诱导痰IL 8[ (10. 24±9. 5)μg/L]与正常对照组比较,有统计学差异(P<0. 01)。结论 不同病因慢性咳嗽患者存在不同气道炎症,咳嗽变异型哮喘、嗜酸性粒细胞支气管炎表现为嗜酸性粒细胞活化为主的多细胞炎症;鼻后滴漏综合征、胃
Objective To investigate the role of induced sputum in evaluating airway inflammation in patients with chronic cough. Methods Eighty - six chronic cough patients were collected from our hospital for sputum cytology classification. ECP and IL - 8 of the supernatants were measured. Results A total of 77 cases were diagnosed. Among them, 24 cases were cough variant asthma, 13 cases were eosinophilic bronchitis, 22 cases were postnasal drip syndrome, 12 cases were gastroesophageal reflux and 6 cases were double etiology. Mice with cough variant asthma and eosinophilic bronchitis induced sputum eosinophils (0.172 ± 0.144, 0.186 ± 0.163), neutrophils .401 ± 0.191), ECP [(3.12 ± 2.12) mg / L, (2.53 ± 2.07) mg / L] and IL8 [(7.44 ± 1.93) μg / L, (7. 63 ± 6. 47) μg / L] and the normal control group [002 ± 0 002; 0 · 223 ± 0 · 102; (1.06 ± 0.98) μg / L] was statistically significant (P <0.01 or P <0.05), but there was no significant difference between the two groups. Post-nasal drip syndrome and gastroesophageal reflux group induced sputum neutrophil (0. 555 ± 0.288,0. 504 ± 0. 304) compared with the normal control group was statistically significant (P <0. 01). The post-nasal drip syndrome induced sputum IL 8 [(10. 24 ± 9.5) μg / L] compared with the normal control group, there was a significant difference (P <0.01). Conclusion There are different airway inflammation, cough variant asthma and eosinophilic bronchitis in patients with different causes of chronic cough.