目的:建立测定重酒石酸卡巴拉汀胶囊含量的高效液相色谱法。方法:选用5C18-MS-Ⅱ色谱柱(4.6 mm×250 mm,5μm);流动相:甲醇-水(90∶10);检测波长:217 nm;流速:1.0 mL.min-1;进样量:20μL;柱温:室温。结果:方法的线性范围为:10.9~163.5μg.mL-1,回归方程为:A=2.829×104C-4.103×104(r=0.9997,n=6);日内精密度RSD为1.6%(n=5),日间精密度为1.2%;回收率在97.2%~98.2%之间,RSD在0.72%~1.2%(n=9)。结论:方法简便灵敏,结果准确可靠,可用于重酒石酸卡巴拉汀胶囊的质量控制。 Objective: To establish a HPLC method for the determination of rivastigmine bitartrate capsules. Methods: The 5C18-MS-Ⅱ column (4.6 mm × 250 mm, 5 μm) was used as the mobile phase. The mobile phase consisted of methanol and water (90:10), the detection wavelength was 217 nm, the flow rate was 1.0 mL.min-1. : 20 μL; column temperature: room temperature. Results: The linear range of the method was 10.9 ~ 163.5μg.mL-1, the regression equation was: A = 2.829 × 104C-4.103 × 104 (r = 0.9997, n = 6) 5). The intraday precision was 1.2%. The recovery rates ranged from 97.2% to 98.2% with RSDs ranging from 0.72% to 1.2% (n = 9). Conclusion: The method is simple and sensitive, accurate and reliable, and can be used for the quality control of rivastigmine-loaded rivastigmine capsules.