胰岛素抵抗是2型糖尿病的主要发病机制之一,而骨骼肌是胰岛素抵抗的重要外周组织。目前认为骨骼肌细胞内脂质含量过多,尤其是游离脂肪酸(free fat acid,FFA)的异常蓄积,是骨骼肌胰岛素抵抗的重要原因。肌组织内增多的脂肪将比葡萄糖优先利用,导致肌细胞利用葡萄糖能力下降,摄取 Insulin resistance is one of the main pathogenesis of type 2 diabetes, and skeletal muscle is an important peripheral tissue of insulin resistance. At present, it is thought that the excessive accumulation of lipid in skeletal muscle cells, especially the abnormal accumulation of free fatty acid (FFA), is an important factor of skeletal insulin resistance. Increased intramuscular fat will be given priority over glucose, resulting in a decrease in muscle cells’ ability to utilize glucose, uptake