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目的：研究禁食２４ｈ的离体鼠心对去甲肾上腺素（ＮＥ）和异丙肾上腺素（ＩＳＯ）的反应。方法：用每４ｍｉｎ含不同浓度的ＮＥ或ＩＳＯ的Ｋ－Ｈ液灌流进食和禁食离体鼠心。连续记录了左心室发展压（ＬＶＤＰ）和心率（ＨＲ）。结果：对ＩＳＯ和ＮＥ反应的量效曲线均右移。对ＩＳＯ反应的禁食鼠的ＥＣ５０高于进食鼠（禁食鼠１．００Ｅ－７．７１２±０．０４２６，进食鼠１．００Ｅ－８．２８±０．０５１５ｎ＝４，Ｐ＜０．００１）；对ＮＥ反应的心律失常发生率明显低于进食鼠（禁食鼠４６．８０±６．３４次／３２分，进食鼠８３．８０±１０．１８次／３２分，ｎ＝５，Ｐ＜０．０１）。对ＩＳＯ反应两组心律失常发生率无明显差异。结论：禁食鼠心对ＮＥ和ＩＳＯ的反应均受抑制。这对心肌有保护作用。
AIM: To investigate the response of isolated rat hearts to fastidious 24h for norepinephrine (NE) and isoproterenol (ISO). Methods: In vitro rat hearts were fed and fasted with K-H solution containing different concentrations of NE or ISO every 4 minutes. Left ventricular developmental pressure (LVDP) and heart rate (HR) were recorded continuously. Results: The QE curves for both ISO and NE responses shifted to the right. The EC50 of fasted rats responding to ISO was higher than that of fed rats (1.00E-7.712 ± 0.0426 for fasted rats, 1.00E-8.28 ± 0.0515n = 4, P <0.001 for fed rats ). The incidence of arrhythmia in response to NE was significantly lower than that in fed rats (46.80 ± 6.34 times / 32 minutes in fasting rats, 83.80 ± 10.18 times / 32 minutes in rats, n = 5, P <0.01). There was no significant difference in the incidence of arrhythmia between the two groups on ISO response. Conclusions: The fasting rat heart to NE and ISO responses were inhibited. This has a protective effect on the myocardium.