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目的:研究甲氨蝶呤与恩丹西酮、格拉司琼配伍的稳定性。方法:采用紫外分光光度法考察甲氨蝶呤与恩丹西酮、格拉司琼在8h内的吸收度变化情况,同时观察外观、pH值及薄层层析检查。结果:在室温条件下,甲氨蝶呤与格拉司琼在0-8h内外观稳定,特征峰吸收度、pH值无明显变化,薄层层析检查无新物质产生。甲氨蝶呤与恩丹西酮在0-8h内含量、pH值亦均无明显变化。二者的低浓度稀释混合液外观稳定,但甲氨蝶呤(1mg/ml)与恩丹西酮(2mg/ml)混合有沉淀产生。结论:甲氨蝶呤与格拉司琼在生理盐水中可以配伍使用。甲氨蝶呤与恩丹西酮由于在浓度高时会析出沉淀,故不宜在生理盐水中使用。
Objective: To study the stability of compatibility between methotrexate and ondansetron and granisetron. Methods: The changes of absorption of methotrexate, ondansetron and granisetron within 8h were observed by UV spectrophotometry. Meanwhile, the appearance, pH and TLC were also examined. Results: At room temperature, methotrexate and granisetron within 0-8h stable appearance, the characteristic peak absorption, pH no significant change, no new material produced by TLC. Methotrexate and ondansetron in 0-8h content, pH value also had no significant change. Both of the low concentration dilution mixture appearance stable, but methotrexate (1mg / ml) and ondansetron (2mg / ml) were mixed precipitation. Conclusion: Methotrexate and granisetron can be used in normal saline. Methotrexate and ondansetron due to precipitation at high concentrations will precipitate, it is not appropriate to use in normal saline.