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目的观察丹参酮ⅡA磺酸钠注射液联合辛伐他汀治疗冠心病心绞痛的临床疗效和安全性。方法 98例冠心病心绞痛患者随机分为试验组49例与对照组49例。试验组口服辛伐他汀10 mg·d~(-1),静脉滴注丹参酮ⅡA磺酸钠60mg·d~(-1),加入250 m L葡萄糖溶液中。对照组口服辛伐他汀10 mg·d~(-1)。2组疗程均为1个月。比较2组的临床疗效、血脂、心功能、血流动力学水平,并观察2组不良反应发生情况。结果试验组总有效率为87.75%,显著高于对照组的71.43%(P<0.05)。2组血脂水平各指标治疗后均较治疗前显著下降(P<0.05),试验组显著低于对照组(P<0.05)。2组心功能水平各指标治疗后均较治疗前增加(P<0.05),试验组显著高于对照组(P<0.05);2组血流动力学各指标治疗后均较治疗前显著下降(P<0.05),试验组显著低于对照组(P<0.05)。治疗期间均无严重不良反应发生。结论丹参酮ⅡA磺酸钠注射液联合辛伐他汀治疗冠心病心绞痛临床疗效显著,可明显改善患者的血脂、心功能及血流动力学,且安全可靠。
Objective To observe the clinical efficacy and safety of tanshinone Ⅱ A sodium sulfonate injection combined with simvastatin in the treatment of angina pectoris. Methods A total of 98 patients with coronary heart disease and angina pectoris were randomly divided into experimental group (49 cases) and control group (49 cases). The experimental group was given simvastatin 10 mg · d ~ (-1) orally and the tanshinone Ⅱ A sulfonate 60 mg · d ~ (-1) was intravenously dripped into 250 mL dextrose solution. The control group was given simvastatin 10 mg · d ~ (-1) orally. 2 groups of treatment are 1 month. The clinical efficacy, blood lipid, cardiac function and hemodynamics of the two groups were compared, and the occurrence of adverse reactions in the two groups were observed. Results The total effective rate of the experimental group was 87.75%, which was significantly higher than that of the control group (71.43%, P <0.05). The levels of serum lipid in each group were significantly lower than those before treatment (P <0.05), and the levels in the experimental group were significantly lower than those in the control group (P <0.05). Compared with the control group, the indexes of cardiac function in the two groups were significantly increased after treatment (P <0.05), and were significantly higher in the experimental group than those in the control group (P <0.05). The indexes of hemodynamics in the two groups were significantly decreased P <0.05), the experimental group was significantly lower than the control group (P <0.05). No serious adverse reactions occurred during the treatment. Conclusion Tanshinone Ⅱ A sodium sulfonate injection combined with simvastatin has a significant clinical effect on angina pectoris. It can significantly improve the blood lipid, cardiac function and hemodynamics of patients and is safe and reliable.