心房利钠利尿肽原(pro-atrial natriuretic peptide,proANP)在蛋白水解酶corin的作用下分解为众多小分子片段,包括氨基端前体片段(NT-proANP)、长效利钠利尿肽(long-acting natriuretic peptide,LANP)、血管舒张肽(vessel dilator)、利钾利尿肽(kaliuretic peptide,KP)、尿舒血管素(urodilatin)和羧基端的心房利钠利尿肽(atrial natriuretic peptide,ANP)等。近年发现这些活性片段不仅各自具有相对独立的生物学效应,而且相互作用,形成复杂的调节网络,在机体稳态维持中具有重要的生理和病理生理意义。 The proANtrial natriuretic peptide (proANP) is decomposed into many small molecule fragments by the action of the protease corin, including NT-proANP, long-acting natriuretic peptide (long -acting natriuretic peptide (LANP), vessel dilator, kaliuretic peptide (KP), urodilatin and atrial natriuretic peptide (ANP) at the carboxy terminus . In recent years, these active fragments not only have their own independent biological effects, but also interact with each other to form a complex regulatory network, which has important physiological and pathophysiological significance in maintaining homeostasis.