12型糖尿病β细胞进行性衰竭目前全球糖尿病流行状况日趋严重,中国20岁以上成人糖尿病患病率9.7%,而糖尿病前期的比例高达15.5%[1],2型糖尿病占糖尿病人群的90%以上,因此控制2型糖尿病对糖尿病总体达标以及预防和治疗糖尿病并发症起着关键性作用。2型糖尿病的特征是胰岛素抵抗和胰岛β细胞进行性衰竭,后者是糖尿病进展和恶化的决定性因素[2],一项PimaIndians随访7年的前瞻性研究发现2型糖尿病发生的预测因子是β细胞功能指标AIRg(葡萄糖刺激后急性胰岛素反应)而不 Currently, the global prevalence of diabetes is worsening. The prevalence of diabetes in adults over the age of 20 in China is 9.7%, compared with 15.5% in pre-diabetes [1]. Type 2 diabetes accounts for more than 90% of diabetic patients , Controlling type 2 diabetes plays a key role in overall diabetes compliance and prevention and treatment of diabetic complications. Type 2 diabetes is characterized by insulin resistance and pancreatic β-cell progressive failure, the latter being a decisive factor in the progression and worsening of diabetes [2]. A prospective study of 7-year follow-up by PimaIndians found that type 2 diabetes predisposes to β AIRg (glucose stimulated acute insulin response) instead