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目的了解铀矿工人尿中8-羟基脱氧鸟苷(8-OHdG)水平。方法随机选择某铀矿99名男性铀矿工为矿工组,包括55名井下矿工和44名水冶矿工,随机选择44名男性行政工作人员或岗前工人为对照组,用酶联免疫吸附法(ELISA)检测其尿中8-OHdG水平,对资料进行χ2检验、方差分析以及多元线性回归分析。结果 55名井下铀矿工尿中8-OHdG水平为(64.91±60.06)ng/mgCr,44名水冶厂铀矿工尿中8-OHdG水平为(52.08±23.31)ng/mgCr,44名对照组工作人员尿中8-OHdG水平为(51.50±29.36)ng/mgCr;3组铀矿工作人员尿中8-OHdG水平差异无统计学意义(F=1.60,P=0.21);井下铀矿工和水冶厂铀矿工工龄为5~9年者尿中8-OHdG水平高于工龄<5年和工龄≥10年的铀矿工,但差异无统计学意义(F=0.65,P=0.53;F=0.85,P=0.44)。结论该研究未发现铀矿工尿中8-OHdG水平高于对照人群;低剂量全身辐射可能会引起DNA损伤适应性反应。
Objective To understand urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) in uranium miners. Methods A total of 99 male uranium miners from a uranium mine, including 55 underground miners and 44 metallurgical miners, were selected randomly. Forty-four male administrative staffs or pre-job workers were randomly selected as the control group. Enzyme-linked immunosorbent assay (ELISA) ) To detect urinary 8-OHdG levels, χ2 test data, analysis of variance and multiple linear regression analysis. Results The urinary 8-OHdG level of 55 underground miners was (64.91 ± 60.06) ng / mgCr. The urinary 8-OHdG level of 44 miners in the hydrometer factory was (52.08 ± 23.31) ng / mgCr, and 44 control group staff The level of 8-OHdG in urine was (51.50 ± 29.36) ng / mgCr. There was no significant difference in urinary levels of 8-OHdG between the three groups of uranium miners (F = 1.60, P = 0.21) The level of 8-OHdG in urine of uranium miners who were 5 to 9 years old was higher than that of uranium miners whose work years were less than 5 years and their working years was longer than 10 years, but the difference was not statistically significant (F = 0.65, P = 0.53; F = 0.85, P = 0.44). Conclusion This study did not find uranium miners urinary 8-OHdG levels higher than the control population; low-dose whole body radiation may cause DNA damage adaptive response.