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用大鼠急性心肌缺血模型，研究新型多巴胺受体激动剂多培沙明（ＤＰＸ）对急性心肌缺血时大鼠心脏血液动力学的影响，并与非诺多泮（ＦＯＤＡ）和丙卡特罗（ＰＣＴ）的效应作比较。结果表明，ｉｖＤＰＸ可明显减轻缺血所致总外周阻力（ＴＰＲ）和左室舒张末压的增高，＋ｄｐ／ｄｔｍａｘ的降低，而对平均动脉血压（ＭＡＰ）无显著性影响。尽管ＦＯＤＡ改善缺血所致ＴＰＲ增高和心肌收缩力减弱的程度大于ＤＰＸ，但它能明显降低ＭＡＰ。提示ＤＰＸ能明显降低ＴＰＲ，轻度增加心肌收缩力改善心功能，而不降低ＭＡＰ和不增加心肌耗氧量，因而用于缺血性心脏病的治疗可能有较好的应用前景。
Acute myocardial ischemia model was used to study the effect of a new dopamine receptor agonist, docetaxel (DPX) on cardiac hemodynamics in rats with acute myocardial ischemia. The effects of fenofibrate (FODA) The effect of Lo (PCT) is compared. The results showed that ivDPX significantly reduced the total peripheral resistance (TPR) and the increase of left ventricular end-diastolic pressure and + dp / dtmax induced by ischemia, but had no significant effect on mean arterial pressure (MAP). Although FODA improved ischemic-induced TPR increased and myocardial contractility weakened more than DPX, but it can significantly reduce the MAP. Tip DPX can significantly reduce TPR, mildly increased myocardial contractility to improve cardiac function, without reducing the MAP and does not increase myocardial oxygen consumption, which for the treatment of ischemic heart disease may have a better application prospects.