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目的:探讨冠状动脉介入治疗(PCI)对冠心病患者白细胞介素-18(IL-18)和高敏C反应蛋白(hsCRP)血清水平的影响。方法:随机选取32例不稳定型心绞痛患者,30例急性心肌梗死患者,均行PCI,并于术前5min、术后即刻、术后6h、24h、术后1个月采取外周动脉血,测定IL-18、hsCRP的血清水平。结果:PCI后即刻、6h、24hIL-18、hsCRP水平均高于术前,其差异有统计学意义(P<0.05),术后1个月与术前比较差异无统计学意义。结论:PCI术可能在短期内触发并加重了冠状动脉炎症反应。
Objective: To investigate the effect of percutaneous coronary intervention (PCI) on serum levels of interleukin-18 (IL-18) and high-sensitivity C-reactive protein (hsCRP) in patients with coronary heart disease. Methods: Thirty-two patients with unstable angina pectoris and 30 patients with acute myocardial infarction were enrolled in the study. Peripheral arterial blood was collected at 5 min before operation, 6 h, 24 h after operation and 1 month after operation. Serum levels of IL-18, hsCRP. Results: The levels of IL-18 and hsCRP at 6h, 24h after PCI were significantly higher than those before operation (P <0.05). There was no significant difference at 1 month after PCI between preoperative and postoperative levels. Conclusion: PCI may trigger and aggravate the inflammation of the coronary artery in a short time.