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目的:比较短效达必佳2种降调节方案在控制性超排卵(COH)中的效果。方法:回顾性分析比较本中心接受COH降调节方案的261个周期,根据达必佳用量及用法的不同分成A组:部分半量方案,95个周期;B组:半量方案,166个周期,比较组间的超促排卵情况及妊娠结局。结果:A组Gn用量(75IU/支)、Gn总天数、IVF受精率和优质胚胎率均较B组高(P<0.05);Gn启动日FSH水平和hCG注射日LH水平较B组低(P<0.05);着床率、临床妊娠率、继续妊娠率A组与B组比差异无统计学意义(P<0.05),但有增高趋势。结论:黄体中期短效达必佳0.1mg/d×14d降调节效果比0.05mg/d降调节好。
Objective: To compare the effects of short-acting dabigatran-2 regimen in controlled ovarian hyperstimulation (COH). METHODS: A retrospective analysis of 261 cycles of COH lowering regimen was performed in our center. The patients were divided into group A according to the amount and usage of maxillofacil: partial half dose regimen, 95 cycles; group B: half dose regimen, 166 cycles, Ovulation between groups and pregnancy outcomes. Results: The Gn dosage (75IU / branch), Gn total days, IVF fertilization rate and high quality embryo rate in group A were higher than those in group B (P <0.05). The levels of FSH in Gn on the day of initiation and LH on the day of hCG injection were lower than those in group B P <0.05). There was no significant difference in implantation rate, clinical pregnancy rate and continuing pregnancy rate between A group and B group (P <0.05), but there was an increasing trend. Conclusion: The mid-term luteal phase of daobang good 0.1mg / d × 14d down regulation effect than 0.05mg / d down regulation.