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目的 探讨儿童哮喘发作期与缓解期血免疫球蛋白和T细胞亚群的动态变化及临床意义 ;方法 应用免疫荧光技术对 38例哮喘患儿的哮喘发作期与缓解期和 2 0例健康对照儿童的外周血免疫球蛋白和T细胞亚群进行测定 ;结果 (1 )哮喘发作期lgG ;1 1 .83± 7.54与对照组 1 0 .1 6± 2 .65比较有显著差异 (P <0 .0 5) ;(2 )哮喘发作期及缓解期CD3 +、CD4+、CD4+/CD8+值与正常对照组比较有显著差异 (P <0 .0 5) ;发作期及缓解期CD8+与对照组比较无明显差异 (P >0 .0 5) ;结论 儿童哮喘存在着lgG的改变 ,CD4+T细胞增加 ,CD8+T细胞数量或和功能不足导致免疫功能紊乱是哮喘的主要发病机制。
Objective To investigate the dynamic changes and clinical significance of blood immunoglobulin and T cell subsets in asthmatic children during the onset and remission period.Methods Immunofluorescence was used to detect the asthma exacerbation and remission in 38 asthmatic children and 20 healthy children Of peripheral blood immunoglobulin and T cell subsets were measured; Results (1) asthma exacerbation lgG; 1183 ± 7.54 compared with the control group of 10.6 ± 2.65 significant difference (P <0. (2) There were significant differences in CD3 +, CD4 +, CD4 + / CD8 + values between the onset and remission stages of asthma and the control group (P <0.05); CD8 + (P0.05) .Conclusion There are lgG changes in children with asthma, CD4 + T cells increased, the number of CD8 + T cells and dysfunction leading to immune dysfunction is the main pathogenesis of asthma.