1970年Field 和Caspary 首次试用巨噬细胞泳动试验(MEM)诊断人类恶性疾病。该次试验的理论基础是:恶性肿瘤患者血液中已被致敏的淋巴细胞在体外与特异性抗原接触后,可产生一种“巨噬细胞移动致缓因子(MSF)”。MSF 使巨噬细胞表面的电荷发生变化,进而影响其在电场内的移动速度。根据巨噬细胞在电场内泳动速度的改变可间接检测MSF 的存在与否。1973年,Pritchard 等对MEM 的实验方法进行了改良。此后,很多学 In 1970 Field and Caspary first trial of macrophage migration test (MEM) diagnosis of human malignancies. The rationale for this trial is that lymphocytes that have been sensitized in the blood of patients with malignancies produce a “macrophage migration promoting factor (MSF)” after they have been exposed to specific antigens in vitro. MSF changes the charge on the surface of macrophages, which in turn affects the speed of movement within the electric field. The presence or absence of MSF can be measured indirectly based on changes in the rate of migration of macrophages in the electric field. In 1973, Pritchard et al. Improved the experimental method of MEM. Since then, a lot of learning