雌二醇及雌酮都曾由卵巢组织内分离证实(1,2)。近年来利用同位素标记的雌激素进行研究的结果亦说明两个激素是卵巢的分泌的原型雌激素,并相应地阐明了它们的代谢途径和产物,(3,4)包括雌三醇,16—表雌三醇,16α—羟基雌酮,16β—羟基雌酮,16氧—17β—雌二醇,以及2—甲氧基雌酮等(表一),此外尚有2—甲氧基 Both estradiol and estrone have been isolated from ovarian tissue (1, 2). In recent years, studies using isotope-labeled estrogens have also shown that two hormones are the prototypical estrogens secreted by the ovary and that their metabolic pathways and products are elucidated accordingly. (3,4) includes estriol,16— Table estriol, 16α-hydroxyestrone, 16β-hydroxyestrone, 16oxyl-17β-estradiol, and 2-methoxyestrone, etc. (Table 1), and 2-methoxy