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尿液中存在IgG、IgM、血清型IgA和分泌型IgA(sIgA),其中sIgA的主要部分来源于膀胱和泌尿道上皮细胞,极小部分由肾小管合成。SIgA由二聚体IgA分子和分泌成份(SC)构成。临床上,sIgA具有防御胃肠道、呼吸道细菌侵袭的重要作用。IgA系统,尤其是sIgA,在尿液中的作用尚不清楚。体外实验表明:尿液中sIgA具有潜在的保护功能,其主要作用是防止细菌在尿道上皮细胞的粘附。体内研究显示:当细菌感染时尿液中血清型IgA和sIgA浓度均增高,因此sIgA可能有预防尿路感染(UTI)的作用。本文旨在研究长期原因不明的复发性尿感(rUTI)的女性患者尿液sIgA、游离分泌成份(FSC)和血清型IgA的变化,以了解相对性sIgA的缺乏可能与患者血清型IgA或SC生成减少有关。 68名健康女性为正常对照组,年龄19-49岁。将患者分为4组:A组,10例三年内尿感次数≥5,而近期无症状的rUTI,无尿路异常。B组,8例为近期无症状的
Urine contains IgG, IgM, serogroup IgA, and secreted IgA (sIgA). The main part of sIgA is derived from bladder and urothelial cells, and the most part is synthesized by tubules. SIgA consists of dimeric IgA molecules and secreted components (SC). Clinically, sIgA has an important role in preventing gastrointestinal and respiratory bacterial invasion. The role of IgA systems, especially sIgA, in urine is unclear. In vitro experiments show that: sIgA in urine has a potential protective function, its main role is to prevent the adhesion of bacteria in the urethral epithelium. In vivo studies have shown that when IgA and sIgA levels are elevated in urine during bacterial infections, sIgA may have the effect of preventing urinary tract infections (UTIs). This article aims to investigate changes in urinary sIgA, freesecretory component (FSC) and serogroup IgA in female patients with long-term unexplained recurrent urine (rUTI) in order to understand the relative lack of sIgA that may be associated with seropositive IgA or SC Generated reduction related. 68 healthy women as normal control group, aged 19-49 years. The patients were divided into 4 groups: Group A, 10 cases of urine flu within three years ≥ 5, while the recent asymptomatic rUTI, no urinary tract abnormalities. B group, 8 cases were asymptomatic recently