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目的观察芪药消渴胶囊与葛根芩连汤对高脂膳食诱导追赶生长模型大鼠IR及IL-6、TNF-α的影响。方法采用限食后开放高脂膳食法复制追赶生长大鼠模型,观察用芪药消渴胶囊、葛根芩连汤灌胃给药8 W后大鼠血糖、血脂、胰岛素、胰岛素抵抗指数、IL-6、TNF-α的变化。结果芪药消渴胶囊(0.6、1.8 g/kg)剂量、葛根芩连汤(6.5、3.25 g/kg)剂量能改善追赶生长大鼠胰岛素抵抗(P<0.05),降低细胞炎症因子IL-6、TNF-α的分泌(P<0.05)。结论芪药消渴胶囊、葛根芩连汤均能改善高脂膳食致追赶生长模型大鼠IR,降低IL-6、TNF-α的分泌,提示对减轻或延缓糖尿病的发生和发展具有一定的作用,且芪药消渴胶囊的作用优于葛根芩连汤。
Objective To observe the effect of Qixiao Xiaoke Capsule and Gegen Qinlian Decoction on IR, IL-6 and TNF-α in rats induced by high-fat diet. Methods After the rats were sacrificed, the rats were sacrificed and the rats were sacrificed by open high fat diet. The rats were treated with Qixiaxiaozai capsule and Gegen Qinlian decoction for 8 weeks. The blood glucose, blood lipid, insulin, insulin resistance index, IL- 6, TNF-α changes. Results The dosages of Qixiaoxiaoke Capsule (0.6,1.8 g / kg) and Gegen Qinlian Decoction (6.5,3.25 g / kg) can improve insulin resistance (P <0.05) and reduce the expression of cytokines IL-6 , Secretion of TNF-α (P <0.05). CONCLUSIONS: Qiqi Xiaoke Capsule and Gegen Qinlian Decoction can both improve the IR of high-fat diet-induced growth model rats and decrease the secretion of IL-6 and TNF-α, suggesting that they may play a role in reducing or retarding the occurrence and development of diabetes mellitus , And the role of Qi Diabetes Capsule better than Gegen Qin Lian Tang.