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目的在临床上小剂量联合使用咪达唑仑、丙泊酚、芬太尼对重型颅脑损伤的治疗效果。方法 120例重型颅脑损伤的患者,随机分为实验组和对照组,各60例,对照组进行常规治疗,实验组在常规治疗的基础上进行镇痛镇静剂:小剂量咪达唑仑、丙泊酚、芬太尼联合治疗。结果实验组与对照组生命体征相比较差异无统计学意义(P>0.05);实验组与对照组疼痛情况、躁动情况、住ICU时间、住院时间、死亡率、颅内压和预后数值相比,差异有统计学意义(P<0.05)。结论小剂量联合使用咪达唑仑、丙泊酚、芬太尼用于重型颅脑损伤患者镇静治疗,可减少重型颅脑手术损伤患者术后意外的发生,同时联合用药发挥药物的协同作用以提高效果,减少用药量,从而减少毒副作用,降低了费用而且达到了良好的效果。
Objective To reduce the clinical effect of midazolam, propofol and fentanyl on severe craniocerebral injury. Methods One hundred and twenty cases of severe craniocerebral injury were randomly divided into experimental group and control group, 60 cases in each group. The control group received routine treatment. The experimental group received analgesic and sedatives on the basis of routine treatment: low dose midazolam, Propofol, fentanyl combination therapy. Results There was no significant difference in the vital signs between the experimental group and the control group (P> 0.05). Compared with the control group, pain scores, restlessness, ICU stay, hospital stay, mortality, intracranial pressure and prognosis , The difference was statistically significant (P <0.05). Conclusion Low-dose combination of midazolam, propofol and fentanyl for sedation in patients with severe craniocerebral injury can reduce the incidence of postoperative accidents in patients with severe craniocerebral injury, and the synergistic effects of the drugs Improve the effect, reduce the dosage, thereby reducing the toxic side effects, reduce costs and achieve good results.