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目的探讨缺氧诱导因子-1α(hypoxia inducible factor-1,HIF-1α)、血管内皮生长因子-C(vascular endothelial growth factor-C,VEGF-C)和VEGF受体-3(vascular endothelial growth factor receptor-3,VEGFR-3)蛋白在前列腺癌组织中的表达及意义。方法应用免疫组织化学SP法测定64例前列腺癌和15例正常前列腺组织中HIF-1α、VEGF-C和VEGFR-3蛋白的表达情况。结果 HIF-1α、VEGF-C和VEGFR-3蛋白在前列腺癌组织中的表达率分别为60.9%、70.3%和71.9%,在正常前列腺组织中均无表达;HIF-1α蛋白的表达与病理分级、临床分期和淋巴转移有关,VEGF-C蛋白与病理分级和淋巴转移有关,VEGFR-3蛋白与淋巴转移有关(P<0.05);在前列腺癌组织中HIF-1α与VEGF-C、VEGFR-3;VEGF-C与VEGFR-3的表达呈正相关(P<0.05)。结论前列腺癌组织中HIF-1α、VEGF-C和VEGFR-3蛋白的高表达与前列腺癌的发生及淋巴转移相关。
Objective To investigate the expression of hypoxia inducible factor-1 (HIF-1α), vascular endothelial growth factor-C (VEGF-C) and vascular endothelial growth factor receptor -3, VEGFR-3) in prostate cancer tissue and its significance. Methods The expressions of HIF-1α, VEGF-C and VEGFR-3 in 64 cases of prostate cancer and 15 cases of normal prostate tissue were detected by immunohistochemical SP method. Results The positive rates of HIF-1α, VEGF-C and VEGFR-3 in prostate cancer tissue were 60.9%, 70.3% and 71.9%, respectively, which were not found in normal prostate tissue. The expression of HIF- , Clinical stage and lymph node metastasis. VEGF-C protein was associated with pathological grade and lymphatic metastasis, and VEGFR-3 protein was correlated with lymphatic metastasis (P <0.05). HIF-1αand VEGF-C, VEGFR-3 ; VEGF-C and VEGFR-3 expression was positively correlated (P <0.05). Conclusion The high expressions of HIF-1α, VEGF-C and VEGFR-3 in prostate cancer tissues are associated with the occurrence of prostate cancer and lymphatic metastasis.